VRTX

Healthcare

Vertex Pharmaceuticals Incorporated · Biotechnology · $110B

UQS Score — Balanced Preset
70.3
Good

Vertex Pharmaceuticals Incorporated scores 70.3/100 using the Balanced preset.

UQS vs Healthcare Sector
VRTX
70.3
Sector avg
32.4
Quality
Strong
Moat
Neutral
Growth
Good
Risk
Strong
Valuation
Neutral

VRTX Price History

+109.3% over 5Y

Monthly close, adjusted for stock splits and dividend reinvestment.

Return Calculator

What if I invested in Vertex Pharmaceuticals Incorporated?

$
Today it would be worth
$19,831
That's a +98.3% total return, or +14.7% annualized.

Based on Vertex Pharmaceuticals Incorporated's historical closing prices, adjusted for stock splits and dividend reinvestment. Past performance does not guarantee future results. This is for informational purposes only and is not financial advice.

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Pro Analysis

VRTX — Score History

6065707580Apr 2Apr 12Apr 22May 2May 12May 22May 23v5
Score changes· 18 most recent
DateUQSQualityMoatGrowthRiskValueChange
May 22, 202670.484.455.063.0100.053.10.0
May 21, 202670.484.455.063.0100.053.0+0.1
May 17, 202670.384.355.063.1100.052.5+0.2
May 15, 202670.184.155.063.1100.051.50.0
May 13, 202670.184.155.063.1100.051.3-0.3
May 12, 202670.484.455.063.1100.052.70.0
May 10, 202670.484.455.063.1100.053.1+0.7
May 7, 202669.781.455.063.599.153.30.0
May 6, 202669.781.455.063.599.153.60.0
May 5, 202669.781.455.063.699.153.7-0.1

VRTX — Pillar Breakdown

Quality

84.4/100 (25%)

Vertex Pharmaceuticals Incorporated demonstrates outstanding capital efficiency and profitability, placing it among the highest-quality businesses in the market.

Capital Efficiency (ROIC)Strong

How effectively capital is deployed to generate returns.

Return on EquityStrong

Profitability relative to shareholders' equity.

Operating ProfitabilityStrong

Ability to convert revenue into operating profit.

Net ProfitabilityStrong

Bottom-line profit as a share of revenue.

Gross Profit / AssetsStrong

Asset productivity — how much gross profit each dollar of assets generates.

Cash GenerationModerate

Free cash flow relative to market value.

Growth

63.0/100 (20%)

Vertex Pharmaceuticals Incorporated demonstrates healthy growth trends across revenue and earnings.

Recent Revenue TrendWeak

Revenue trajectory over the last twelve months.

3Y Revenue CAGRWeak

Compound annual revenue growth rate over 3 years.

EPS GrowthStrong

Year-over-year earnings per share growth.

Forward Revenue OutlookModerate

Analyst consensus for future revenue growth.

Forward EPS GrowthStrong

Analyst consensus for future earnings growth.

Risk

100.0/100 (15%)

Vertex Pharmaceuticals Incorporated carries minimal financial risk with conservative leverage and strong solvency.

Financial LeverageStrong

Debt levels relative to earnings capacity.

Debt/EquityStrong

Total debt relative to shareholder equity.

Current RatioStrong

Short-term liquidity — ability to pay near-term obligations.

Interest CoverageStrong

Earnings capacity relative to interest payments.

Valuation

52.6/100 (15%)

Vertex Pharmaceuticals Incorporated has a mixed valuation — some metrics suggest fair value while others appear stretched.

Earnings YieldModerate

Inverse of forward P/E — higher yield means cheaper stock.

Price to Free Cash FlowModerate

How many years of FCF the market cap represents.

PEG RatioStrong

P/E relative to earnings growth — lower is more attractive.

EV/EBITDA vs SectorWeak

Enterprise value multiple relative to sector median.

Moat

55/100 (25%)

Vertex Pharmaceuticals Incorporated has meaningful competitive advantages that should protect its market position. The Moat pillar evaluates competitive advantages across five dimensions: Switching Costs, Network Effects, Cost Advantage, Intangible Assets, and Scale & Ecosystem. Sign in to customize moat ratings for VRTX.

Score Composition

Quality
84.4×25%21.1
Growth
63.0×20%12.6
Risk
100.0×15%15.0
Valuation
52.6×15%7.9
Moat
55.0×25%13.8
Total
70.3Good

Financial Data

More Stock Analysis

How is the VRTX UQS Score Calculated?

The UQS (Unified Quality Score) for Vertex Pharmaceuticals Incorporated is calculated using a proprietary 6-pillar framework with 29 financial metrics. Each pillar evaluates a different dimension on a 0–100 scale, then combines into a single weighted score. Scoring thresholds are calibrated per sector. Momentum is an optional Pro toggle — without it, you get the 5-pillar / 25-metric core shown below.

Quality (25%) measures profitability and capital efficiency — ROIC, ROE, margins, GP/Assets, and FCF Yield.

Moat (25%) assesses Vertex Pharmaceuticals Incorporated's competitive advantages across switching costs, network effects, cost advantages, intangible assets, and ecosystem scale.

Growth (20%) tracks revenue trajectory and earnings momentum, combining historical results with analyst forward estimates.

Risk (15%) is inversely scored — lower leverage and strong balance sheet health result in higher scores.

Valuation (15%) measures whether Vertex Pharmaceuticals Incorporated is fairly priced using earnings yield, price-to-FCF, PEG ratio, and EV/EBITDA relative to sector peers.

Six investor-inspired presets are available, each with different pillar weights: Balanced, Buffett, Munger, Lynch, Cathie Wood, and Graham. The public score shown here uses the Balanced preset. Learn more in our FAQ.