GRAL

Healthcare

GRAIL, Inc. · Medical - Diagnostics & Research · $3B

UQS Score — Balanced Preset
38.7
Below Average

GRAIL, Inc. scores 38.7/100 using the Balanced preset.

UQS vs Healthcare Sector
GRAL
38.7
Sector avg
32.4
Quality
Weak
Moat
Weak
Growth
Strong
Risk
Good
Valuation
Elevated

What is GRAIL, Inc.?

GRAIL, Inc. is a biotechnology company focused on early cancer detection through multi-cancer screening technology. Based in Menlo Park, California, GRAIL aims to shift cancer diagnosis from late-stage discovery to early, asymptomatic identification — a potentially transformative shift in oncology care.

GRAIL develops blood-based tests that screen for cancer signals before symptoms appear. Its flagship product, Galleri, targets asymptomatic individuals over 50 and screens for multiple cancer types from a single blood draw. The company also offers DAC, a diagnostic aid for patients with clinical suspicion of cancer, and is advancing minimal residual disease tests to monitor patients after treatment. Revenue is generated through test sales and partnerships with healthcare systems and payers.

GRAIL was incorporated in 2015 and is headquartered in Menlo Park, California.

  • Galleri — multi-cancer early detection screening test for asymptomatic adults
  • DAC — diagnostic aid for clinically suspected cancer cases
  • Minimal residual disease tests for post-treatment cancer monitoring
  • Genomic sequencing-based liquid biopsy technology platform

Is GRAL a Good Stock to Buy?

UQS Score rates GRAL as Below Average overall, reflecting a mixed profile where exceptional growth potential is offset by meaningful structural weaknesses.

GRAL's Growth pillar stands out as its clearest strength, reflecting the rapid commercial expansion of its early detection platform and the scale of the addressable market. The Risk pillar also registers as Good, suggesting the company's financial positioning and operational risk profile are more manageable than many early-stage biotech peers.

Both the Quality and Moat pillars rate as Weak, pointing to limited profitability and a competitive advantage that has yet to solidify. The Valuation pillar registers as Elevated, meaning the market is pricing in significant future success.

See the exact pillar breakdown and full financial metrics by signing up for a UQS Pro account. Sign up free →

Past performance does not guarantee future results. UQS Score is based on fundamental data and is not a buy/sell recommendation.

Does GRAL pay dividends?

No — GRAIL, Inc. does not currently pay a dividend.

GRAL does not currently pay a dividend. As an early-stage biotech company investing heavily in clinical development and commercial expansion, capital is directed toward growth initiatives rather than shareholder distributions. Investors in GRAL are typically seeking long-term capital appreciation tied to the adoption of its cancer screening platform rather than income.

When does GRAL report earnings?

GRAIL, Inc. reports earnings on a quarterly cadence, consistent with standard practice for US-listed equities.

As a commercial-stage biotech, GRAIL's quarterly results tend to reflect the pace of Galleri test adoption, partnership agreements, and ongoing investment in clinical evidence generation. Revenue growth has been a key focus, though the company continues to operate at a loss as it scales its platform.

For the most recent quarter's results and guidance, visit GRAIL's official investor relations page.

GRAL Price History

+290.2% over 5Y

Monthly close, adjusted for stock splits and dividend reinvestment.

Return Calculator

What if I invested in GRAIL, Inc.?

$
Today it would be worth
$14,991
That's a +49.9% total return, or +49.9% annualized.

Based on GRAIL, Inc.'s historical closing prices, adjusted for stock splits and dividend reinvestment. Past performance does not guarantee future results. This is for informational purposes only and is not financial advice.

GRAL Long-term Outlook

GRAL's fundamental outlook is shaped by the tension between a Strong Growth profile and Weak Quality and Moat ratings. The company operates in a nascent but large market — multi-cancer early detection — where clinical adoption and reimbursement coverage will be the primary growth levers. An Elevated Valuation pillar signals that the current price reflects optimistic long-term assumptions, leaving limited margin for execution shortfalls. The Good Risk rating provides some reassurance that near-term financial stability is not an immediate concern.

Growth drivers

  • Expanding clinical adoption of Galleri among healthcare systems and screening programs
  • Potential reimbursement coverage decisions by major US payers
  • Pipeline advancement of post-diagnostic and minimal residual disease tests

Key risks

  • Weak Moat rating reflects limited competitive differentiation as rivals develop similar liquid biopsy platforms
  • Elevated Valuation leaves little room for commercial execution delays
  • Ongoing operating losses tied to heavy R&D and commercialization spending

GRAL vs Peers

GRAIL operates in a competitive diagnostics and genomics landscape alongside companies pursuing adjacent detection and sequencing technologies.

NEOGSimilar UQS
Neogen Corporation

Neogen focuses on food and animal safety diagnostics rather than human oncology, representing a distinct market application of detection technology.

BLLNGRAL scores lower
BillionToOne, Inc.

BillionToOne develops molecular diagnostic tests including prenatal and oncology applications, competing in the liquid biopsy and rare variant detection space.

TWSTSimilar UQS
Twist Bioscience Corporation

Twist Bioscience provides synthetic DNA tools and genomic reagents that underpin sequencing-based diagnostics, positioning it as both a supplier and indirect competitor in the genomics ecosystem.

Frequently Asked Questions

What does GRAIL do?

GRAIL develops blood-based tests designed to detect cancer signals before symptoms appear. Its lead product, Galleri, screens for multiple cancer types in a single test. The company also offers a diagnostic aid for patients with suspected cancer and is building out post-treatment monitoring tests.

Does GRAL pay dividends?

No, GRAL does not pay a dividend. The company is in an active growth and investment phase, directing capital toward clinical development and commercial expansion of its cancer screening platform rather than shareholder distributions.

When does GRAL report earnings?

GRAIL reports on a quarterly cadence standard for US-listed companies. Because specific upcoming dates are subject to change, check GRAIL's investor relations page for the most current earnings schedule.

Is GRAL a good stock to buy?

UQS Score rates GRAL as Below Average overall. The Growth pillar is Strong and the Risk pillar is Good, but Quality and Moat both rate as Weak, and Valuation is Elevated. Whether that profile suits your portfolio depends on your risk tolerance and investment horizon. The full pillar breakdown is available to Pro members.

Is GRAL overvalued?

GRAL's Valuation pillar is rated Elevated by UQS Score, indicating the market is pricing in substantial future growth. For a pre-profit biotech, this is common — but it does mean execution risk is high. View the complete valuation metrics with a Pro account.

How does GRAL compare to its competitors?

GRAIL's closest peers in the diagnostics and genomics space include Neogen Corporation, BillionToOne, and Twist Bioscience. Each pursues different market segments within detection and sequencing technology. GRAIL's specific focus on multi-cancer early detection from a single blood draw is a distinguishing characteristic of its commercial strategy.

What is GRAL's market cap bracket?

GRAL is classified as a mid-cap company. This places it in a range where institutional coverage is growing but liquidity and volatility can differ meaningfully from large-cap healthcare names.

Who founded GRAIL?

GRAIL was spun out of Illumina and incorporated in 2015. Its founding was closely tied to Illumina's leadership and scientific teams focused on applying next-generation sequencing to cancer detection. Detailed founding history is publicly available through GRAIL's corporate disclosures.

Is GRAL a long-term quality investment?

As a long-term quality indicator, GRAL's profile is mixed. The Strong Growth pillar reflects meaningful commercial momentum, but Weak Quality and Moat ratings suggest the business has not yet built durable profitability or a clearly defensible competitive position. Long-term conviction would depend on reimbursement outcomes and clinical adoption trends.

What is the main competitive advantage of GRAIL?

GRAIL's primary differentiation is its Galleri test, which screens for signals from dozens of cancer types in a single blood draw — a capability built on proprietary methylation-based sequencing technology. However, the UQS Moat pillar rates as Weak, reflecting that this advantage has not yet translated into a clearly defensible market position.

What sector does GRAL belong to?

GRAL operates in the Healthcare sector, specifically within the biotechnology and molecular diagnostics industry. Its focus on cancer screening places it at the intersection of genomics, clinical diagnostics, and preventive oncology — a segment attracting significant investment and regulatory attention.

Is GRAL a growth stock or value stock?

Based on its UQS profile, GRAL is firmly a growth-oriented stock. The Growth pillar rates as Strong while the Valuation pillar is Elevated, a combination typical of high-expectation companies where investors are paying a premium for future potential rather than current earnings.

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Pro Analysis

GRAL — Score History

30354045Apr 2Apr 16Apr 30May 14May 28Jun 11Jun 12v5
Score changes· 2 most recent
DateUQSQualityMoatGrowthRiskValueChange
May 23, 202638.70.039.088.474.80.0+0.6
Apr 2, 202638.10.039.088.471.40.0

GRAL — Pillar Breakdown

Quality

0.0/100 (25%)

GRAIL, Inc. currently shows below-average quality metrics, suggesting challenges with profitability.

Capital Efficiency (ROIC)Weak

How effectively capital is deployed to generate returns.

Return on EquityWeak

Profitability relative to shareholders' equity.

Operating ProfitabilityWeak

Ability to convert revenue into operating profit.

Net ProfitabilityWeak

Bottom-line profit as a share of revenue.

Cash GenerationWeak

Free cash flow relative to market value.

Growth

88.4/100 (20%)

GRAIL, Inc. is growing rapidly with strong revenue and earnings expansion.

Recent Revenue TrendModerate

Revenue trajectory over the last twelve months.

3Y Revenue CAGRStrong

Compound annual revenue growth rate over 3 years.

EPS GrowthStrong

Year-over-year earnings per share growth.

Forward Revenue OutlookStrong

Analyst consensus for future revenue growth.

Risk

74.8/100 (15%)

GRAIL, Inc. maintains a reasonable risk profile with manageable debt levels.

Financial LeverageStrong

Debt levels relative to earnings capacity.

Debt/EquityStrong

Total debt relative to shareholder equity.

Current RatioStrong

Short-term liquidity — ability to pay near-term obligations.

Interest CoverageWeak

Earnings capacity relative to interest payments.

Valuation

0.0/100 (15%)

GRAIL, Inc. appears expensively valued relative to its fundamentals and growth prospects.

Moat

39/100 (25%)

GRAIL, Inc. possesses some competitive advantages but faces meaningful competition. The Moat pillar evaluates competitive advantages across five dimensions: Switching Costs, Network Effects, Cost Advantage, Intangible Assets, and Scale & Ecosystem. Sign in to customize moat ratings for GRAL.

Score Composition

Quality
0.0×25%0.0
Growth
88.4×20%17.7
Risk
74.8×15%11.2
Valuation
0.0×15%0.0
Moat
39.0×25%9.8
Total
38.7Below Average

Financial Data

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How is the GRAL UQS Score Calculated?

The UQS (Unified Quality Score) for GRAIL, Inc. is calculated using a proprietary 6-pillar framework with 29 financial metrics. Each pillar evaluates a different dimension on a 0–100 scale, then combines into a single weighted score. Scoring thresholds are calibrated per sector. Momentum is an optional Pro toggle — without it, you get the 5-pillar / 25-metric core shown below.

Quality (25%) measures profitability and capital efficiency — ROIC, ROE, margins, GP/Assets, and FCF Yield.

Moat (25%) assesses GRAIL, Inc.'s competitive advantages across switching costs, network effects, cost advantages, intangible assets, and ecosystem scale.

Growth (20%) tracks revenue trajectory and earnings momentum, combining historical results with analyst forward estimates.

Risk (15%) is inversely scored — lower leverage and strong balance sheet health result in higher scores.

Valuation (15%) measures whether GRAIL, Inc. is fairly priced using earnings yield, price-to-FCF, PEG ratio, and EV/EBITDA relative to sector peers.

Six investor-inspired presets are available, each with different pillar weights: Balanced, Buffett, Munger, Lynch, Cathie Wood, and Graham. The public score shown here uses the Balanced preset. Learn more in our FAQ.